Tvorko M S, Kalashnik S A, Kovalova E N
Antibiotiki. 1984 Apr;29(4):257-60.
The combined effect of bile acids and antibiotics on the moderately sensitive and resistant staphylococcal strains was studied. 10 staphylococcal cultures isolated from patients with different pyo-inflammatory diseases were tested for their sensitivity to 5 antibiotics (benzylpenicillin, ampicillin, erythromycin, kanamycin and chlortetracycline). 9 of them were moderately sensitive to the drugs. The combined use of these antibiotics with cholic, desoxycholic , dehydrocholic, glycocholic and choleic acids increased the sensitivity of the staphylococci to the drugs in 87 per cent of the cultures. The same regularity was observed with respect to 15 staphylococcal strains isolated from the patients' bile. The combination of taurocholic acid and streptomycin was the most effective. The combinations of the antibiotics with cholic acid were less effective. The same regularities were noted in the experiments with billicultures tested for antibiotic sensitivity on solid media with the patient's bile. Antibiotics with maximum activity associated with the presence of the patient's bile should be recommended for the treatment of patients with inflammatory diseases of the liver and urinary tract.
研究了胆汁酸和抗生素对中度敏感及耐药葡萄球菌菌株的联合作用。对从不同脓性炎症疾病患者中分离出的10株葡萄球菌培养物进行了对5种抗生素（苄青霉素、氨苄青霉素、红霉素、卡那霉素和金霉素）的敏感性测试。其中9株对这些药物中度敏感。这些抗生素与胆酸、脱氧胆酸、脱氢胆酸、甘胆酸和胆酸联合使用，使87%的培养物中的葡萄球菌对药物的敏感性增加。从患者胆汁中分离出的15株葡萄球菌菌株也观察到了同样的规律。牛磺胆酸和链霉素的组合最有效。抗生素与胆酸的组合效果较差。在用患者胆汁在固体培养基上测试抗生素敏感性的双培养实验中也注意到了同样的规律。对于患有肝脏和泌尿系统炎症疾病的患者，应推荐使用与患者胆汁存在相关的活性最高的抗生素进行治疗。
