Gillum R F, Paffenbarger R S
Am J Epidemiol. 1978 Oct;108(4):289-98. doi: 10.1093/oxfordjournals.aje.a112622.
The relationship between sociocultural mobility and subsequent coronary heart disease (CHD) and hypertension (HT) was studied in a cohort of 13,728 male former Harvard University students examined in 1939-1950. All 13,728 were followed for CHD mortality, while 8852 returned self-administered mail questionnaires in 1962 or 1966 and in 1972 which queried for doctor-diagnosed myocardial infarction (MI), angina pectoris (AP) and HT. For each of 98 cases of fatal CHD, 78 cases of MI and 48 cases of AP, four controls were randomly selected. One control was selected for each of 319 HT cases. Significant negative associations between father's occupational status and risk of combined fatal CHD and MI and between geographic mobility and risk of HT were noted in univariate analysis. These associations persisted with stratification by individual confounding factors and by a multivariate confounder-summarizing score. Intergenerational mobility, as indicated by occupational status of the father, was associated with a 1.5 times increased risk of fatal CHD and MI. Intragenerational geographic mobility was associated with a slightly reduced risk of HT.
在1939年至1950年间接受检查的13728名哈佛男性校友队列中，研究了社会文化流动性与随后的冠心病（CHD）和高血压（HT）之间的关系。对所有13728人进行冠心病死亡率随访，而8852人在1962年、1966年和1972年返回了自行填写的邮寄问卷，问卷询问了医生诊断的心肌梗死（MI）、心绞痛（AP）和HT情况。对于98例致命冠心病、78例心肌梗死和48例心绞痛病例，每组随机选择4名对照。对于319例高血压病例，每组选择1名对照。单因素分析显示，父亲的职业地位与致命性冠心病和心肌梗死合并风险之间，以及地域流动性与高血压风险之间存在显著负相关。这些关联在按个体混杂因素分层以及按多变量混杂因素汇总评分后仍然存在。父亲的职业地位所表明的代际流动性与致命性冠心病和心肌梗死风险增加1.5倍相关。代内地域流动性与高血压风险略有降低相关。
