Borea P A
Boll Soc Ital Biol Sper. 1981 Mar 30;57(6):628-32.
The antipentylenetetrazole activity of 35 benzodiazepines has been quantitatively correlated, according to the Hansch model, to the physico-chemical parameters of the substituents. The activities, in the series of compounds under examination, appear to be correlated in a quantitative way to the overall lipophilicity of the molecules and to the presence of highly electron-withdrawing substituents in positions 7 and 2'.
根据Hansch模型，35种苯二氮卓类药物的抗戊四氮活性已与取代基的物理化学参数进行了定量关联。在所研究的化合物系列中，活性似乎与分子的整体亲脂性以及7位和2'位上高吸电子取代基的存在呈定量相关。
