Parola M, Curzio M, Negro F, Paradisi L, Torrielli M V
Boll Soc Ital Biol Sper. 1981 Mar 30;57(6):638-44.
Oral administration of Indomethacin (3 mg/Kg) and Phenylbutazone (200 mg/Kg) induces an increase of TBA reacting substances (TBArs) by total liver homogenates, while treatment with Ibuprofen(200 mg/Kg, os) does not affect the susceptibility of liver tissue to lipid peroxidation. The former compounds do not influence the pro-oxidant action of CCl4 (1,0 ml/Kg, os) as evaluated "in vitro", whereas Ibuprofen appears to limit the extension of the TBArs production induced by the halomethane. The acute inflammatory state determined by carrageenan injection in the rat hind paw does not interfere with the peroxidative derangement found "in vitro" neither in the presence or in the absence of the all mentioned chemicals. Carbon tetrachloride (1,0 ml/Kg, os) is able in depressing significantly the rat paw oedema provoked by carrageenan, but does not potentiates the anti-inflammatory action of non-steroid agents.
口服吲哚美辛（3毫克/千克）和保泰松（200毫克/千克）会使全肝匀浆中与TBA反应的物质（TBArs）增加，而用布洛芬（200毫克/千克，口服）治疗则不会影响肝组织对脂质过氧化的敏感性。就“体外”评估而言，前两种化合物不会影响四氯化碳（1.0毫升/千克，口服）的促氧化作用，而布洛芬似乎能限制卤代甲烷诱导的TBArs产生的程度。角叉菜胶注射到大鼠后爪所确定的急性炎症状态，无论在有或没有所有上述化学物质的情况下，都不会干扰“体外”发现的过氧化紊乱。四氯化碳（1.0毫升/千克，口服）能够显著减轻角叉菜胶诱发的大鼠爪水肿，但不会增强非甾体类药物的抗炎作用。
