[Experimental studies on the possibility of influencing mast cells in experimental carrageenin-induced rat paw edema. Histological study on the effects of some non-steroidal anti-inflammatory agents (author's transl)].

The protective effect on mast cells of some non-steroid antiphlogistics in the carrageenin-induced edema of the rat hind paw was studied with histological methods. The number of the mast cells was counted in the inflamed connective tissue of unpretreated animals and also such pretreated with acetylsalicylacid, phenylbutazone and indometacin and the results of the test periods were compared with one another. The number of mast cells in the inflamed connective tissue of unpretreated animals was reduced in comparison to the controls during the first 5-35 min after inflammation. Six hours after inflammation the number of mast cells increased. Our investigations demonstrated that the used antiphlogistics produced a significant reduction of mast cell degeneration during the first 5-70 min after inflammation. The results are discussed.