静脉注射头孢拉定在有丙磺舒和无丙磺舒情况下的药代动力学。
Pharmacokinetics of cephradine given intravenously with and without probenecid.
作者信息
Roberts D H, Kendall M J, Jack D B, Welling P G
出版信息
Br J Clin Pharmacol. 1981 Jun;11(6):561-4. doi: 10.1111/j.1365-2125.1981.tb01171.x.
Abstract
1 In the light of questions raised by an earlier oral study (Welling, Dean, Selen, Kendall & Wise, 1979) the influence of probenecid on the pharmacokinetics of intravenously administered cephradine has been investigated. 2 Intravenous administration of cephradine resulted in a bi-exponential curve and the level of antibiotic after 15 min was significantly greater when subjects received probenecid than when they did not. The influence of probenecid on urinary excretion of cephradine was similar to that observed previously. 3 The increase in serum of cephradine due to probenecid could be accounted for by the decrease in the elimination rate of the antibiotic. These results are discussed in the light of other observations.
摘要
- 鉴于早期一项口腔研究（韦林、迪恩、塞伦、肯德尔和怀斯，1979年）提出的问题，对丙磺舒对静脉注射头孢拉定药代动力学的影响进行了研究。2. 静脉注射头孢拉定产生了双指数曲线，当受试者接受丙磺舒时，15分钟后抗生素水平显著高于未接受丙磺舒时。丙磺舒对头孢拉定尿排泄的影响与之前观察到的相似。3. 丙磺舒导致头孢拉定血清水平升高可归因于抗生素消除率的降低。根据其他观察结果对这些结果进行了讨论。
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Pharmacokinetics of cephradine given intravenously with and without probenecid.静脉注射头孢拉定在有丙磺舒和无丙磺舒情况下的药代动力学。
Br J Clin Pharmacol. 1981 Jun;11(6):561-4. doi: 10.1111/j.1365-2125.1981.tb01171.x.
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