Minn F L, Sugarman A A, Bernfeld G E
J Clin Pharmacol. 1976 Apr;16(4):171-3. doi: 10.1002/j.1552-4604.1976.tb01513.x.
In a random crossover study, ten healthy men were pretreated with ammonium chloride or sodium bicarbonate to alter urinary pH, and then were given a single 1-Gm dose of cephradine, either orally or intravenously. No significant changes were found in the terminal phase rate constant nor in the time or magnitude of peak concentration. Total recovery was greater than 90 per cent whenever degradation of cephradine did not occur. An unexplained but significant reduction in area under curve was present in data for prealkalinized subjects and for all subjects who took cephradine orally. Trapping of cephradine was not significant in the excretory pathway.
在一项随机交叉研究中，对10名健康男性先用氯化铵或碳酸氢钠预处理以改变尿液pH值，然后口服或静脉给予单剂量1克头孢拉定。终末相速率常数、达峰时间或峰浓度大小均未发现显著变化。只要头孢拉定未发生降解，总回收率就大于90%。在碱化前受试者及所有口服头孢拉定的受试者的数据中，曲线下面积出现了无法解释但显著的降低。头孢拉定在排泄途径中的潴留不显著。
