Marciniak E, Gockerman J P
Br J Haematol. 1981 Aug;48(4):617-25. doi: 10.1111/j.1365-2141.1981.00617.x.
The rate of elimination of injected antithrombin III (AT III) concentrate was investigated by measuring plasma AT III levels in two control subjects and four patients treated with continuous intravenous infusion of heparin. No significant differences were noted in the disappearance rate of injected AT III between controls and patients receiving heparin for several days. Their half-time of AT III elimination was 8.4--13.6 h. The patient in whom AT III concentrate was injected at the start of heparin therapy showed a very rapid decrease of AT III activity with a three-fold increase in the elimination rate constant. Inactive, modified AT III protein present in purified AT III concentrate was found in the circulation of all injected patients. No evidence was obtained that this altered AT III was eliminated more rapidly than the unaltered AT III or that it was subjected to accelerated clearance during heparin therapy.
通过测量两名对照受试者和四名接受肝素持续静脉输注治疗的患者的血浆抗凝血酶III（AT III）水平，研究了注射用AT III浓缩物的消除速率。在对照者和接受肝素治疗数天的患者之间，注射用AT III的消失速率未发现显著差异。其AT III消除半衰期为8.4 - 13.6小时。在肝素治疗开始时注射AT III浓缩物的患者，其AT III活性迅速下降，消除速率常数增加了三倍。在所有注射患者的循环中均发现纯化的AT III浓缩物中存在无活性的、修饰的AT III蛋白。没有证据表明这种改变的AT III比未改变的AT III消除得更快，或者在肝素治疗期间其清除加速。
