Le-Phat H, Awad J, Guidoin R, Bibaud R, Picard R, Blais P
Biomater Med Devices Artif Organs. 1980;8(4):309-32. doi: 10.3109/10731198009118987.
The definite advantage in oxygen transfer performance of staged (single, double and triple) tubular membrane oxygenators (TMO) is compared with reference to flat membrane oxygenators (Travenol or Landé Edwards). The overall construction of staged TMO with a blood mixing chamber is a very good way to destroy the blood boundary layer and modify the blood stagnant zone in the device. Four sizes of staged TMO were studied using the principle that gases dissolve in water in concentrations linearly proportional to the partial pressures of the gases when in equilibrium with the liquid. The experimental results show that the oxygen transfer rate and the corresponding overall oxygen mass transfer coefficient of staged TMO are increased by the same order as those of the reference membrane oxygenators. Furthermore the essential parameter analysis prove that oxygen transfer increases with the number of stages and decreases with the length of the blood tubular modules. The multistage design of TMO revealed an increase in the hydrodynamic resistance occurring in the apparatus. However the highest relative oxygen transfer efficiency suggests that better fluid distribution as well as better uniformity of oxygenation prevail in the staged devices.
将分级（单级、双级和三级）管状膜式氧合器（TMO）在氧气传输性能方面的明确优势与平板膜式氧合器（特拉文诺尔或兰迪·爱德华兹）进行了比较。带有血液混合腔的分级TMO的整体构造是破坏血液边界层并改变装置内血液停滞区的一种非常好的方式。使用气体在与液体平衡时在水中的溶解浓度与气体分压成线性比例的原理，研究了四种尺寸的分级TMO。实验结果表明，分级TMO的氧气传输速率和相应的总氧气传质系数与参考膜式氧合器的增加幅度相同。此外，基本参数分析证明，氧气传输随着级数的增加而增加，随着血液管状模块长度的增加而减少。TMO的多级设计显示装置中出现的流体动力学阻力增加。然而，最高的相对氧气传输效率表明，分级装置中存在更好的流体分布以及更好的氧合均匀性。
