Atkin N B, Amin S, Brito-Babapulle V
Cancer Genet Cytogenet. 1981 Jan;3(1):75-80. doi: 10.1016/0165-4608(81)90058-3.
The majority of metaphases in the bone marrow of a male patient aged 72 with a rapidly evolving aleukemic erythremic myelosis had 48 chromosomes with three copies, or 49 chromosomes with four copies, of an i(17q), which was seen to be dicentric in C-banded and Giemsa-11-banded preparations. There was also loss of a chromosome No. 5 and the addition of a chromosome resembling a No. 22. The presence of multiple copies of the isochromosome is postulated to be related to the acuteness of the condition.
一名72岁男性患者，患有快速进展的无白血病红细胞增多性骨髓增生症，其骨髓中的大多数中期细胞有48条染色体，其中i(17q)有三份拷贝，或49条染色体，其中i(17q)有四份拷贝。在C带和吉姆萨-11带标本中，该等臂染色体显示为双着丝粒。此外，还存在5号染色体缺失以及一条类似22号染色体的染色体增加。推测等臂染色体多拷贝的存在与病情的急性程度有关。
