Goodgame R W, Colley D G, Draper C C, Lewis F A, McLaren M L, Pelley R P
Am J Trop Med Hyg. 1978 Nov;27(6):1174-80. doi: 10.4269/ajtmh.1978.27.1174.
The development of hepatosplenic schistosomiasis in humans cannot always be related to the intensity of infection. A study was designed to identify different humoral immunologic responses to Schistosoma mansoni in patients with and without hepatosplenic disease. Twenty-four patients with active hepatosplenic disease were closely matched for age, sex, and fecal egg counts with twenty-four patients with only intestinal disease. A serum sample from each of these patients was tested for antibodies to the major soluble egg antigen (MSA1) by radioimmunoassay, for total and IgM antibodies to egg and worm antigenic preparations by ELISA, and for its ability to suppress antigen stimulated lymphocyte blastogenesis. No difference was found using these assays between the hepatosplenic and the intestinal schistosomiasis patients.
人类肝脾型血吸虫病的发展并不总是与感染强度相关。一项研究旨在确定有和没有肝脾疾病的曼氏血吸虫病患者对曼氏血吸虫的不同体液免疫反应。24例活动性肝脾疾病患者在年龄、性别和粪便虫卵计数方面与24例仅患有肠道疾病的患者进行了密切匹配。通过放射免疫测定法检测这些患者每个人的血清样本中针对主要可溶性虫卵抗原（MSA1）的抗体，通过酶联免疫吸附测定法检测针对虫卵和虫体抗原制剂的总抗体和IgM抗体，并检测其抑制抗原刺激的淋巴细胞增殖的能力。使用这些检测方法未发现肝脾型血吸虫病患者和肠道血吸虫病患者之间存在差异。
