Ultrastructural analysis of pancreatic carcinogenesis. II. Establishment and morphology of a transplantable hamster pancreatic adenocarcinoma, FCP.

Hamster pancreatic adenocarcinomas were induced by life-time treatment with N-nitroso-bis(2-hydroxypropyl)amine; two of these transplanted subcutaneously into adult hamster recipients. One tumour, designated FCP, continued to grow and has been maintained through 8 serial transplant generations. The morphology and ultrastructure of FCP are described. It is relatively slow-growing, well-differentiated tumour that exhibits a stable growth rate and fine structure and closely resembles both primary hamster pancreatic adenocarcinomas and the human disease, and thus appears to be suitable for use in further biochemical and chemotherapeutic studies.