Flaks B, Moore M A, Flaks A
Carcinogenesis. 1981;2(12):1241-53. doi: 10.1093/carcin/2.12.1241.
Electron and high resolution light microscope studies were made of the pseudoductular structures that develop in the pancreas of the Syrian hamster during chronic treatment with the pancreatocarcinogen, N-nitroso-bis(2-hydroxypropyl)amine (BHP). These pseudoductules, which precede the development of tumours, arise from acini, whose cells undergo dedifferentiation by selective autophagy of their zymogen granules and granular endoplasmic reticulum. It is proposed that the pseudoductules develop into the ultrastructurally similar cystic foci that appear to be the immediate precursors of pancreatic tumours in this experimental model. The possibility is discussed that the acinar cells are the primary target for BHP carcinogenesis.
利用电子显微镜和高分辨率光学显微镜对叙利亚仓鼠胰腺在长期接受胰腺致癌物N-亚硝基双（2-羟丙基）胺（BHP）处理过程中形成的假导管结构进行了研究。这些在肿瘤形成之前出现的假导管起源于腺泡，腺泡细胞通过对其酶原颗粒和粗面内质网进行选择性自噬而发生去分化。有人提出，在该实验模型中，假导管会发展为超微结构相似的囊性病灶，而这些囊性病灶似乎是胰腺肿瘤的直接前体。文中还讨论了腺泡细胞是BHP致癌作用主要靶点的可能性。
