邻二卤化合物的结构与其通过与谷胱甘肽结合进行诱变活化之间的关系。 - Suppr

The relation between the structure of vicinal dihalogen compounds and their mutagenic activation via conjugation to glutathione.

作者信息

van Bladeren P J, Breimer D D, Rotteveel-Smijs G M, de Knijff P, Mohn G R, van Meeteren-Wälchli B, Buijs W, van der Gen A

出版信息

Carcinogenesis. 1981;2(6):499-505. doi: 10.1093/carcin/2.6.499.

DOI:10.1093/carcin/2.6.499

PMID:7273330

Abstract

摘要

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The relation between the structure of vicinal dihalogen compounds and their mutagenic activation via conjugation to glutathione.邻二卤化合物的结构与其通过与谷胱甘肽结合进行诱变活化之间的关系。

Carcinogenesis. 1981;2(6):499-505. doi: 10.1093/carcin/2.6.499.

Stereoselective activation of vicinal dihalogen compounds to mutagens by glutathione conjugation.

Biochem Pharmacol. 1979 Aug 15;28(16):2521-4. doi: 10.1016/0006-2952(79)90019-4.

Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: formation of toxic and mutagenic intermediates by cysteine conjugate beta-lyase.

Drug Metab Rev. 1989;20(1):43-83. doi: 10.3109/03602538908994144.

Synthesis and mutagenicity of 3-halogenated and 3,3',5,5'-tetrahalogenated benzidines.3-卤代联苯胺及3,3',5,5'-四卤代联苯胺的合成与致突变性

Mutagenesis. 1987 Mar;2(2):97-9. doi: 10.1093/mutage/2.2.97.

The enzymatic reaction of chlorotrifluoroethylene with glutathione.三氟氯乙烯与谷胱甘肽的酶促反应。

Biochem Biophys Res Commun. 1982 Dec 31;109(4):1339-45. doi: 10.1016/0006-291x(82)91924-6.

Bioactivation of halogenated hydrocarbons.卤代烃的生物活化

J Toxicol Clin Toxicol. 1982 Aug;19(6-7):699-706. doi: 10.3109/15563658208990399.

Activation and detoxication of N-hydroxy-Trp-P-2 by glutathione and glutathione transferases.

Carcinogenesis. 1983 Dec;4(12):1551-7. doi: 10.1093/carcin/4.12.1551.

Activation of alkyl halides by glutathione transferases.

Methods Enzymol. 2005;401:342-53. doi: 10.1016/S0076-6879(05)01021-9.

In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1.饮用水消毒副产物溴二氯甲烷的体外生物转化与遗传毒性：由谷胱甘肽转移酶θ1-1介导的DNA结合

Toxicol Appl Pharmacol. 2004 Mar 1;195(2):166-81. doi: 10.1016/j.taap.2003.11.019.

Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.膳食抗氧化剂对肝脏谷胱甘肽S-转移酶活性的提升及对苯并(a)芘诱变代谢产物的防护作用

Cancer Res. 1978 Dec;38(12):4486-95.

引用本文的文献

Genotoxicity and carcinogenicity testing of 1,2-dibromopropane and 1,1,3-tribromopropane in comparison to 1,2-dibromo-3-chloropropane.

Cell Biol Toxicol. 1994 Aug;10(4):265-79. doi: 10.1007/BF00756766.

Determination of glutathione in biological material by high pressure liquid chromatography.用高压液相色谱法测定生物材料中的谷胱甘肽。

Pharm Weekbl Sci. 1983 Aug 26;5(4):145-8. doi: 10.1007/BF01961471.

Induction of diphtheria toxin-resistant mutants in human cells by halogenated compounds.卤代化合物对人细胞中白喉毒素抗性突变体的诱导作用。

J Cancer Res Clin Oncol. 1983;105(1):111-2. doi: 10.1007/BF00391843.

In vivo and in vitro binding of 1,2-dibromoethane and 1,2-dichloroethane to macromolecules in rat and mouse organs.1,2 - 二溴乙烷和1,2 - 二氯乙烷在大鼠和小鼠器官中与大分子的体内及体外结合

J Cancer Res Clin Oncol. 1984;108(2):204-13. doi: 10.1007/BF00402468.

Research in the Division of Toxicology. The importance of reactive intermediates of drug biotransformation in drug toxicity.毒理学部门的研究。药物生物转化的反应性中间体在药物毒性中的重要性。

Pharm Weekbl Sci. 1985 Apr 26;7(2):67-70. doi: 10.1007/BF02106130.

In vitro microsome- and cytosol-mediated binding of 1,2-dichloroethane and 1,2-dibromoethane with DNA.1,2 - 二氯乙烷和1,2 - 二溴乙烷在体外微粒体和胞质溶胶介导下与DNA的结合

Cell Biol Toxicol. 1985 Jan;1(2):45-55. doi: 10.1007/BF00717790.

Inhalation pharmacokinetics of 1,2-dichloroethane after different dietary pretreatments of male Sprague-Dawley rats.雄性斯普拉格-道利大鼠经不同饮食预处理后1,2-二氯乙烷的吸入药代动力学

Arch Toxicol. 1986 Oct;59(3):127-34. doi: 10.1007/BF00316320.

N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies? A critical evaluation of possibilities and limitations.N-乙酰-S-(2-羟乙基)-L-半胱氨酸作为生物监测研究中的一种潜在工具？对其可能性和局限性的批判性评估。

Arch Toxicol. 1989;63(3):173-84. doi: 10.1007/BF00316366.

Effect of inhalation exposure regimen on DNA binding potency of 1,2-dichloroethane in the rat.吸入暴露方案对大鼠体内1,2 - 二氯乙烷DNA结合能力的影响。

Arch Toxicol. 1991;65(3):169-76. doi: 10.1007/BF02307305.

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The relation between the structure of vicinal dihalogen compounds and their mutagenic activation via conjugation to glutathione.

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