Andreev V C, Boyanov L, Tsankov N
Dermatologica. 1981;163(1):19-24. doi: 10.1159/000250136.
A patient suffering from an advanced and inoperable gastric carcinoma developed an unusual paraneoplastic syndrome, consisting of intensive pruritus, acanthosis nigricans, sign of Leser-Trélat (seborrhoic keratoses and freckles), warty and papillomatous excrescences, palmoplantar hyperkeratosis and florid papillomatous and granular lesions of the mouth mucosa. The whole skin of the patient was involved. The authors believe this disorder to be generalized acanthosis nigricans. As a cause they suggest the possibility of a growth-stimulating factor, produced by the tumor cells. The relationship of acanthosis nigricans with the sign of Leser-Trélat is discussed.
一名患有晚期无法手术的胃癌患者出现了一种不寻常的副肿瘤综合征，包括剧烈瘙痒、黑棘皮病、Leser-Trélat征（脂溢性角化病和雀斑）、疣状和乳头状赘生物、掌跖角化过度以及口腔黏膜的显著乳头状和颗粒状病变。患者的全身皮肤均受累。作者认为这种病症为泛发性黑棘皮病。他们推测病因可能是肿瘤细胞产生的一种生长刺激因子。文中还讨论了黑棘皮病与Leser-Trélat征之间的关系。
