Balázs M, Kovách G
Hepatogastroenterology. 1981 Aug;28(4):199-202.
A case of hepatitis induced by methyldopa and verified by means of challenge with the drugs is reported. The severe, chronic, aggressive inflammation greatly regressed after discontinuing the drug. The clinical differences, as well as those in laboratory findings disappeared. The electron-microscopic showed definite, but non-specific changes in the hepatic and sinusoidal mesenchymal cells. Our case was compared with the electromicroscopic picture of chronic aggressive hepatitis of unknown aetiology, and one essential difference was found in our hepatitis case as a result of methyldopa treatment: pathologic fibrogenesis did not occur. The rapid regression of the severe morphological picture can be attributed to this fact.
报告了1例由甲基多巴引起的肝炎病例，并通过药物激发试验得以证实。停用该药物后，严重的慢性侵袭性炎症明显消退。临床差异以及实验室检查结果的差异均消失。电子显微镜检查显示肝实质细胞和肝血窦间叶细胞有明确但非特异性的变化。将我们的病例与病因不明的慢性侵袭性肝炎的电镜图像进行比较，发现甲基多巴治疗导致的该例肝炎有一个本质区别：未发生病理性纤维生成。严重形态学表现的快速消退可归因于此。
