Sturrock R R
J Anat. 1981 Jan;132(Pt 1):119-36.
The central canal of the adult mouse spinal cord is lined for most of its extent by ependymal cells which are rich in microfilaments and whose apical surface is covered with matted, broad microvilli. The canal itself is filled with amorphous material containing glycogen granules. Two forms of this material are present, a dark form rich in glycogen, and a light form containing a few glycogen granules. Each type appears to be surrounded by a membrane. The upper cervical region, however, has a large empty lumen and the ependymal cells in this region have only scattered, narrow microvilli. During development, the floor and roof plates are at first composed largely of ependymoglial cells, unlike the lateral walls, where undifferentiated neuroepithelial cells predominate. By E15 few undifferentiated neuroepithelial cells remain. At E17 the morphology of the ependymal cells changes. Their apical surface becomes covered with matted, club-shaped microvilli and the central canal is filled with glycogen-containing material. By P5 microfibrils are present in large bundles in the ependymal cells. The piaglial surface opposite the roof and floor plates has finger-like projections unique to these regions and these persist at the surface of the dorsal median septum until myelination is well advanced after P5. The fibres forming the dorsal median septum are at first pale processes containing scattered glycogen granules and microtubules. By P5 microfibrils are present and at P150 the processes are packed with masses of microfibrils.
成年小鼠脊髓的中央管大部分长度由室管膜细胞衬里，这些细胞富含微丝，其顶端表面覆盖着交织在一起的宽微绒毛。管腔内充满含有糖原颗粒的无定形物质。这种物质有两种形式，一种深色形式富含糖原，另一种浅色形式含有少量糖原颗粒。每种类型似乎都被一层膜包围着。然而，上颈段有一个大的空管腔，该区域的室管膜细胞只有散在的窄微绒毛。在发育过程中，底板和顶板最初主要由室管膜胶质细胞组成，这与侧壁不同，侧壁中未分化的神经上皮细胞占主导。到胚胎第15天（E15），很少有未分化的神经上皮细胞留存。在胚胎第17天（E17），室管膜细胞的形态发生变化。它们的顶端表面被交织在一起的棒状微绒毛覆盖，中央管充满含糖原物质。到出生后第5天（P5），室管膜细胞中有大量成束的微原纤维。与顶板和底板相对的软膜表面有这些区域特有的指状突起，这些突起在背正中隔表面持续存在，直到出生后第5天（P5）髓鞘形成进展良好。形成背正中隔的纤维最初是浅色突起，含有散在的糖原颗粒和微管。到出生后第5天（P5）出现微原纤维，到出生后第150天（P150），突起中充满大量微原纤维。
