弗氏菌素的化学修饰。II. 弗氏菌素A和B的选择性保护。
Chemical modification of fortimicins. II. Selective protection of fortimicins A and B.
作者信息
Sato M, Mochida K, Mori Y, Shirahata K
出版信息
J Antibiot (Tokyo). 1981 May;34(5):513-21. doi: 10.7164/antibiotics.34.513.
The four amino groups of fortimicin B(4) could be differentiated from each other and 2'-N-benzyloxycarbonyl-, 2',6'-di-N-benzyloxycarbonyl-, 2'-N-tert-butoxycarbonyl-, 6'-N-tert-butoxycarbonyl- and 2',6'-di-N-tert-butoxycarbonyl-fortimicin B (7, 8, 16, 18, 17) were prepared from 4. From these fortimicin B derivatives, selectively protected fortimicin A derivatives 13, 15, 21, 22 and 25 were prepared by combination of procedures of benzyloxycarbonylation or tert-butoxycarbonylation, 4-N-glycylation.
福提霉素B(4)的四个氨基可以相互区分，并且由4制备了2'-N-苄氧羰基-、2',6'-二-N-苄氧羰基-、2'-N-叔丁氧羰基-、6'-N-叔丁氧羰基-和2',6'-二-N-叔丁氧羰基-福提霉素B(7、8、16、18、17)。通过苄氧羰基化或叔丁氧羰基化、4-N-糖基化的步骤组合，从这些福提霉素B衍生物制备了选择性保护的福提霉素A衍生物13、15、21、22和25。
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