福提霉素C、D和KE的结构。

The structures of fortimicins C, D, and KE.

作者信息

Iida T, Sato M, Matsubara I, Mori Y, Shirahata K

出版信息

J Antibiot (Tokyo). 1979 Dec;32(12):1273-9. doi: 10.7164/antibiotics.32.1273.

DOI:10.7164/antibiotics.32.1273

Abstract

Fortimicins C, D, and KE are new aminocyclitol antibiotics produced by a mutant of fortimicin-producing organisms. Their structures have been determined by 1H and 13C NMR and mass spectra and chemical degradations. Fortimicin C is 4-N-hydantoylfortimicin B, fortimicin KE is 6'-demethylfortimicin B, and fortimicin D is 4-N-glycylfortimicin KE. The last two antibiotics have purpurosamine C instead of 6-epi-purpurosamine B.

摘要

福提霉素C、D和KE是由产福提霉素的生物体突变体产生的新型氨基环醇抗生素。它们的结构已通过1H和13C核磁共振、质谱以及化学降解得以确定。福提霉素C是4-N-乙内酰脲基福提霉素B，福提霉素KE是6'-去甲基福提霉素B，福提霉素D是4-N-甘氨酰福提霉素KE。后两种抗生素含有紫罗胺C而非6-表-紫罗胺B。