新氨基糖苷类抗生素福提霉素A和B。III. 结构鉴定。
Fortimicins A and B, new aminoglycoside antibiotics. III. Structural identification.
作者信息
Egan R S, Stanaszek R S, Cirovic M, Mueller S L, Tadanier J, Martin J R, Collum P, Goldstein A W, De Vault R L, Sinclair A C, Fager E E, Mitscher L A
出版信息
J Antibiot (Tokyo). 1977 Jul;30(7):552-63. doi: 10.7164/antibiotics.30.552.
The structures of fortimicins A and B have been determined by PMR, CMR, mass spectra and CD combined with chemical degradations. Both antibiotics are pseudodisaccharides and incorporate a novel aminocyclitol, fortamine. In contrast to the diaminocyclitol moieties of known aminoglycosides, fortamine is a 1,4-diamine, contains both N- and O-methyl groups and possesses chiro stereochemistry. Both antibiotics are glycosides of 6-epi-purpurosamine B, but fortimicin A differs from fortimicin B by being a glycyl amide.
通过质子磁共振谱（PMR）、碳磁共振谱（CMR）、质谱和圆二色光谱（CD）并结合化学降解法确定了福提霉素A和B的结构。这两种抗生素都是假二糖，并含有一种新型氨基环醇，即福提胺。与已知氨基糖苷类的二氨基环醇部分不同，福提胺是一种1,4 - 二胺，含有N - 甲基和O - 甲基基团，并且具有手性立体化学结构。这两种抗生素都是6 - 表 - 紫霉素胺B的糖苷，但福提霉素A与福提霉素B的不同之处在于它是一种甘氨酰胺。
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