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本文引用的文献

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Biochemistry of uric acid and its relation to gout.尿酸的生物化学及其与痛风的关系。
N Engl J Med. 1963 Apr 4;268:764-73 contd. doi: 10.1056/NEJM196304042681406.
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Uric acid production in gout.痛风中的尿酸生成
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Gout and blood dyscrasias.痛风与血液系统疾病。
Medicine (Baltimore). 1959 May;38(2):173-205. doi: 10.1097/00005792-195905000-00004.
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The contribution of residual nephrons within the chronically diseased kidney to urate homeostasis in man.慢性疾病肾脏中的残余肾单位对人体尿酸稳态的贡献。
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Urine uric acid to creatinine rtio--a screening test for inherited disorders of purine metabolism. Phosphoribosyltransferase (PRT) deficiency in X-linked cerebral palsy and in a variant of gout.尿尿酸与肌酐比值——嘌呤代谢遗传性疾病的筛查试验。X连锁脑性瘫痪和痛风一种变异型中的磷酸核糖转移酶（PRT）缺乏症。
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纯合子镰状细胞病患者的血清尿酸盐浓度

Serum urate concentrations in homozygous sickle cell disease.

作者信息

De Ceulaer K, Morgan A G, Choo-Kang E, Wilson W A, Serjeant G R

出版信息

J Clin Pathol. 1981 Sep;34(9):965-9. doi: 10.1136/jcp.34.9.965.

DOI:10.1136/jcp.34.9.965
PMID:7276221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC494205/
Abstract

Serum and urinary urate concentrations were studied in 44 patients with homozygous sickle cell (SS) disease, and in 27 controls with normal haemoglobin. Hyperuricaemia (>0.39 mmol/l (6.5 mg/100 ml)) occurred in 41% of SS patients and inversely correlated with renal urate clearance but not with indices of bone marrow turnover. Higher serum urate concentrations occurred in patients with proteinuria, probably due to associated tubular damage. Higher serum urate concentrations and lower urate clearance occurred in males compared to females.

摘要

对44例纯合子镰状细胞（SS）病患者和27例血红蛋白正常的对照者的血清和尿尿酸盐浓度进行了研究。41%的SS患者出现高尿酸血症（>0.39 mmol/l（6.5 mg/100 ml）），且与肾脏尿酸清除率呈负相关，但与骨髓周转率指标无关。蛋白尿患者的血清尿酸盐浓度较高，可能是由于合并肾小管损伤。与女性相比，男性的血清尿酸盐浓度较高，尿酸清除率较低。