纯合子镰状细胞病患者的血清尿酸盐浓度
Serum urate concentrations in homozygous sickle cell disease.
作者信息
De Ceulaer K, Morgan A G, Choo-Kang E, Wilson W A, Serjeant G R
出版信息
J Clin Pathol. 1981 Sep;34(9):965-9. doi: 10.1136/jcp.34.9.965.
Abstract
Serum and urinary urate concentrations were studied in 44 patients with homozygous sickle cell (SS) disease, and in 27 controls with normal haemoglobin. Hyperuricaemia (>0.39 mmol/l (6.5 mg/100 ml)) occurred in 41% of SS patients and inversely correlated with renal urate clearance but not with indices of bone marrow turnover. Higher serum urate concentrations occurred in patients with proteinuria, probably due to associated tubular damage. Higher serum urate concentrations and lower urate clearance occurred in males compared to females.
摘要
对44例纯合子镰状细胞（SS）病患者和27例血红蛋白正常的对照者的血清和尿尿酸盐浓度进行了研究。41%的SS患者出现高尿酸血症（>0.39 mmol/l（6.5 mg/100 ml）），且与肾脏尿酸清除率呈负相关，但与骨髓周转率指标无关。蛋白尿患者的血清尿酸盐浓度较高，可能是由于合并肾小管损伤。与女性相比，男性的血清尿酸盐浓度较高，尿酸清除率较低。
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