Averous M, Guiter J, Grasset D
J Urol (Paris). 1981;87(2):67-75.
In 240 girls aged between three and fifteen years with mictional problems or urological infectious complications, 58 had radiological appearances of urethral stenosis. A complete clinical, urographic, urodynamic, endoscopic and instrumental study was performed in these 58 children. The majority of these young girls suffered from frequency with urgency, enuresis, pyuria and radiological and endoscopic appearances of trabeculated bladder. Thirteen showed signs of vesico-ureteric reflux. A basic fact: only two of the children had meatal stenosis. All the others had a urethral calibre larger than normal. Almost all the children had an unstable bladder, but with the exception of the two girls with a tight meatal stenosis, none had urodynamic data compatible with poor stream or vesico-sphincter dysinergism. The author concluded in the existence and the exceptional nature of true stenosis of the terminal urethra in the young girl. Most often, in the absence of true stenosis, there is nevertheless a functional stenosis related to contraction of the striate sphincter intended to overcome contraction of the unstable bladder. Such non-inhibited bladders are the site of marked disinhibition contractions without any element of outlet obstruction no increase in urethral resistance and no increase in micturation pressures. Disturbances of day and night continence are essential. Vesical trabeculations are a logical consequence, easy to understand, but the episodes of recurrent infection and the development of vesico-ureteric reflux (present in 13 of the girls) are rather more complicated to explain. This pathological state is most often reversible as the bladder matures. Nevertheless, bladder education, pharmacological treatment, dilatations and urethrotomy may help such children. Such treatment has given favourable results in 50% of cases.
在240名年龄在3至15岁之间有排尿问题或泌尿系统感染并发症的女孩中,58名有尿道狭窄的影像学表现。对这58名儿童进行了全面的临床、尿路造影、尿动力学、内镜和器械检查。这些年轻女孩大多有尿频、尿急、遗尿、脓尿以及膀胱小梁化的影像学和内镜表现。13名有膀胱输尿管反流迹象。一个基本事实是:只有两名儿童有尿道口狭窄。其他所有儿童的尿道口径都大于正常。几乎所有儿童都有不稳定膀胱,但除了两名尿道口狭窄严重的女孩外,没有一人的尿动力学数据与尿流不畅或膀胱括约肌协同失调相符。作者得出结论,年轻女孩终末尿道真正狭窄的存在及其特殊性。大多数情况下,在没有真正狭窄时,仍然存在与横纹肌括约肌收缩相关的功能性狭窄,旨在克服不稳定膀胱的收缩。这种无抑制膀胱存在明显的去抑制收缩,没有任何出口梗阻因素,尿道阻力不增加,排尿压力也不增加。昼夜失禁障碍至关重要。膀胱小梁化是一个合乎逻辑的结果,很容易理解,但反复感染发作和膀胱输尿管反流的发生(13名女孩中有此情况)则更难解释。随着膀胱成熟,这种病理状态大多是可逆的。然而,膀胱训练、药物治疗、扩张和尿道切开术可能对这些儿童有帮助。这种治疗在50%的病例中取得了良好效果。