[Hemocoagulatological changes in toxemia of pregnancy--in reference to birth weight (author's transl)].

It is well-known that SFD babies are born of the mothers who had toxemia of pregnancy in many cases. Recently we examined the relation of hemocoagulatological changes in mothers with toxemia to the birth weight of their babies with the intention of investigating the cause of development of SFD babies and obtained some information as follows: 1. The pregnant women with toxemia were significantly lower (p less than 0.01) in platelet count, fibrinogen content, and serum factor XIII value, significantly longer (p less than 0.01) in bleeding time, and significantly higher (p less than 0.01) in serum-urine FDP, platelet ADP aggregation and platelet spreadability than the normal pregnant women. 2. As for the relation of these changes to the birth weight, the value obtained in the SFD baby and that obtained in the AFD baby group were 5.8 +/- 1.5 and 4.5 +/- 1.3 in bleeding time (min), 20.4 +/- 3.17 and 23.4 +/- 4.21 in platelet count x 10(4)/mm3), 296.5 +/- 58.5 and 346.8 +/- 50.4 in fibrinogen content (mg/dl), 1.3 +/- 0.80 and 0.6 +/- 0.63 in urine FDP (microgram/ml), respectively, and the difference between both groups was significant (p less than 0.05) in each of these parameters. The results stated above suggested that toxemia of pregnancy assumed as aspect of chronic DIC and this tendency was stronger in the SFD baby group. From these facts it is considered that a state of chronic DIC in toxemia of pregnancy may be a cause of disturbance in the development of the fetus.