Cutler D J
J Pharmacokinet Biopharm. 1981 Apr;9(2):217-23. doi: 10.1007/BF01068083.
The recirculation equation is examined for the case in which the blood concentration is given by a polyexponential expression sigma Ai exp (-ait). A matrix is developed whose eigenvalues are the exponential coefficients of the single pass response. These eigenvalues are real and distinct, and the single pass response is monotonic decreasing, when the Ai are all positive. An ordering relatión for the eigenvalues is given.
针对血液浓度由多指数表达式(\sum_{i}A_{i}e^{(-a_{i}t)})给出的情况，对再循环方程进行了研究。构建了一个矩阵，其特征值为单次通过响应的指数系数。当所有(A_{i})均为正时，这些特征值是实数且互不相同，并且单次通过响应是单调递减的。给出了特征值的一个排序关系。
