Cutler D J
J Pharmacokinet Biopharm. 1979 Feb;7(1):101-16. doi: 10.1007/BF01059445.
A new approach to the modeling of drug disposition is described. Disposition is regarded as the result of repetitive passes of the drug around the circulation. Mathematical analysis of experimental blood concentration data yields an expression describing the kinetics of a single pass through the tissues. In physicochemical terms the single-pass behavior depends to a large extent on the interaction of the drug with individual tissues, which greatly simplifies interpretation. The method may reveal features of disposition not apparent from experimental blood concentration data.
本文描述了一种药物处置建模的新方法。处置被视为药物在循环系统中反复通过的结果。对实验血药浓度数据进行数学分析，得出一个描述药物单次通过组织动力学的表达式。从物理化学角度来看，单次通过行为在很大程度上取决于药物与各个组织的相互作用，这大大简化了解释。该方法可能揭示出从实验血药浓度数据中不明显的处置特征。
