Castro O, Socha W W, Moor-Jankowski J
J Med Primatol. 1981;10(1):55-60. doi: 10.1159/000460053.
The recovery and survival of small quantities of 51Cr-labelled human erythrocytes (RBCs) transfused to nonhuman primates were measured. In two chimpanzees all of the human RBCs circulated 15 min after transfusion and were subsequently removed from the animals' blood with a half-life (T1/2) of 1.6 and 2.4 days. In baboons and rhesus monkeys over 95% of the human RBCs were cleared within 15 min after injection. Animal species, rather than antibody characteristics or titer, was an important determinant of the human RBC survival. Transfusion of human RBCs to chimpanzees can thus be explored as a test system to study human erythrocyte disorders.
对输注到非人灵长类动物体内的少量51Cr标记的人类红细胞（RBC）的恢复和存活情况进行了测量。在两只黑猩猩中，所有人类RBC在输血后15分钟内循环，随后以1.6天和2.4天的半衰期（T1/2）从动物血液中清除。在狒狒和恒河猴中，超过95%的人类RBC在注射后15分钟内被清除。动物种类而非抗体特性或滴度是人类RBC存活的重要决定因素。因此，将人类RBC输注到黑猩猩体内可作为研究人类红细胞疾病的测试系统进行探索。
