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氨苯砜衍生物及类似物对麻风分枝杆菌的活性。

Activity of derivatives and analogs of dapsone against Mycobacterium leprae.

作者信息

Levy L

出版信息

Antimicrob Agents Chemother. 1978 Nov;14(5):791-3. doi: 10.1128/AAC.14.5.791.

DOI:10.1128/AAC.14.5.791
PMID:727767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352553/
Abstract

Of 25 dapsone derivatives and analogs screened for activity against Mycobacterium leprae in the mouse footpad system, only 7 were active. All seven were metabolized to or contaminated with dapsone.

摘要

在针对小鼠足垫系统中麻风分枝杆菌活性进行筛选的25种氨苯砜衍生物及类似物中，只有7种具有活性。这7种化合物均被代谢为氨苯砜或被氨苯砜污染。

相似文献

1
Activity of derivatives and analogs of dapsone against Mycobacterium leprae.氨苯砜衍生物及类似物对麻风分枝杆菌的活性。
Antimicrob Agents Chemother. 1978 Nov;14(5):791-3. doi: 10.1128/AAC.14.5.791.
2
Bactericidal action of dapsone against Mycobacterium leprae in mice.氨苯砜对小鼠体内麻风分枝杆菌的杀菌作用。
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3
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Susceptibility of thymectomized and irradiated mice to challenge with several organisms and the effect of dapsone on infection with Mycobacterium leprae.胸腺切除和受辐照小鼠对多种病原体攻击的易感性以及氨苯砜对麻风分枝杆菌感染的影响。
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Combined rifampin and dapsone chemotherapy of Mycobacterium leprae infection of the neonatally thymectomized Lewis rat.对新生期胸腺切除的Lewis大鼠麻风分枝杆菌感染进行利福平与氨苯砜联合化疗。
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引用本文的文献

1
Simultaneous detection of Mycobacterium leprae and its susceptibility to dapsone using DNA heteroduplex analysis.使用DNA异源双链分析同时检测麻风分枝杆菌及其对氨苯砜的敏感性。
J Clin Microbiol. 2001 Jun;39(6):2083-8. doi: 10.1128/JCM.39.6.2083-2088.2001.
2
Dihydropteroate synthase of Mycobacterium leprae and dapsone resistance.麻风分枝杆菌的二氢蝶酸合酶与氨苯砜耐药性
Antimicrob Agents Chemother. 2000 Jun;44(6):1530-7. doi: 10.1128/AAC.44.6.1530-1537.2000.

本文引用的文献

1
THE IN VIRTO ACTIVITY OF 4,4'-DIAMINODIPHENYL SULFONE AGAINST VARIOUS ACID-FAST MICROORGANISMS.4,4'-二氨基二苯砜对各种抗酸微生物的体外活性
Int J Lepr. 1963 Apr-Jun;31:183-7.
2
Enzymatic metabolism of drugs and other foreign compounds.药物及其他外来化合物的酶促代谢
Annu Rev Biochem. 1958;27(3):427-54. doi: 10.1146/annurev.bi.27.070158.002235.
3
Absorption, metabolism and excretion of di(rho-aminophenyl) sulphone (dapsone) and di(rho-aminophenyl) sulphoxide in man.人对二（对氨基苯基）砜（氨苯砜）和二（对氨基苯基）亚砜的吸收、代谢及排泄
Br J Pharmacol Chemother. 1966 Jan;26(1):212-7. doi: 10.1111/j.1476-5381.1966.tb01823.x.
4
DDS sensitivity of mycobacteria. Antagonistic effect of PABA for M. ulcerans and M. kansasii.分枝杆菌对二氨基二苯砜的敏感性。对氨基苯甲酸对溃疡分枝杆菌和堪萨斯分枝杆菌的拮抗作用。
Int J Lepr Other Mycobact Dis. 1968 Oct-Dec;36(4):427-31.
5
Activity of repository sulfones against Mycobacterium leprae in mice.储存砜类药物对小鼠体内麻风分枝杆菌的活性。
Proc Soc Exp Biol Med. 1967 Feb;124(2):430-3. doi: 10.3181/00379727-124-31757.
6
Recent bacteriologic, immunologic and pathologic studies on experimental human leprosy in the mouse foot pad.
Int J Lepr. 1965 Jul-Sep;33(3):Suppl:646-57.
7
Deformylation of 4,4'-diformamidodiphenyl sulfone (DFD) by plasma of certain mammals.
Biochem Pharmacol. 1971 Sep;20(9):2409-16. doi: 10.1016/0006-2952(71)90241-3.
8
Disposition of the antileprosy drug, dapsone, in the mouse.抗麻风病药物氨苯砜在小鼠体内的处置情况。
Proc Soc Exp Biol Med. 1972 Jul;140(3):937-43. doi: 10.3181/00379727-140-36584.
9
The minimal inhibitory concentrations of sulphadimethozine and sulphadoxine against Mycobacterium leprae.磺胺二甲氧嘧啶和磺胺多辛对麻风分枝杆菌的最低抑菌浓度。
Lepr Rev. 1970 Oct;41(4):223-8. doi: 10.5935/0305-7518.19700031.
10
Application of spectrophotofluorometric procedures to some problems in Mycobacterium leprae infections in mice and man treated with dapsone (DDS), diacetyl-DDS (DADDS), and di-formyl-DDS (DFD).分光光度荧光法在小鼠和人类麻风分枝杆菌感染中应用于用氨苯砜（DDS）、二乙酰氨苯砜（DADDS）和二甲酰氨苯砜（DFD）治疗的一些问题。
Am J Trop Med Hyg. 1971 Mar;20(2):274-81. doi: 10.4269/ajtmh.1971.20.274.