氨苯砜衍生物及类似物对麻风分枝杆菌的活性。
Activity of derivatives and analogs of dapsone against Mycobacterium leprae.
作者信息
Levy L
出版信息
Antimicrob Agents Chemother. 1978 Nov;14(5):791-3. doi: 10.1128/AAC.14.5.791.
Abstract
Of 25 dapsone derivatives and analogs screened for activity against Mycobacterium leprae in the mouse footpad system, only 7 were active. All seven were metabolized to or contaminated with dapsone.
摘要
在针对小鼠足垫系统中麻风分枝杆菌活性进行筛选的25种氨苯砜衍生物及类似物中，只有7种具有活性。这7种化合物均被代谢为氨苯砜或被氨苯砜污染。
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Absorption, metabolism and excretion of di(rho-aminophenyl) sulphone (dapsone) and di(rho-aminophenyl) sulphoxide in man.人对二（对氨基苯基）砜（氨苯砜）和二（对氨基苯基）亚砜的吸收、代谢及排泄
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Activity of repository sulfones against Mycobacterium leprae in mice.储存砜类药物对小鼠体内麻风分枝杆菌的活性。
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