Levy L
Antimicrob Agents Chemother. 1976 Apr;9(4):614-7. doi: 10.1128/AAC.9.4.614.
Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, and inoculated into additional mice. The organisms recovered from untreated mice multiplied in passage with a mean doubling time of 12.2 days, and 35% or more of the inoculated organisms were viable, i.e., capable of infecting mice. Growth curves of M. leprae recovered from dapsone-treated animals lagged behind those of organisms from control animals by an average of 78 days, equivalent to 98.8% killing. Foot-by-foot harvests showed that only 0.2% of the M. leprae recovered from treated mice were viable, suggesting that treatment of mice with dapsone had been accompanied by killing of 99.4% of the viable M. leprae.
将氨苯砜（4,4'-二氨基二苯砜）以0.1 g/100 g饲料的浓度掺入小鼠食物中，给麻风分枝杆菌已繁殖至10(6)个菌/足垫水平的小鼠喂食1周。从这些小鼠以及对照小鼠中采集麻风分枝杆菌，进行连续稀释，然后接种到其他小鼠体内。从未经处理的小鼠中回收的菌株在传代过程中增殖，平均倍增时间为12.2天，且35%或更多的接种菌株具有活力，即能够感染小鼠。从经氨苯砜处理的动物中回收的麻风分枝杆菌的生长曲线平均比对照动物的菌株滞后78天，相当于98.8%的杀灭率。逐足采集结果显示，从经处理的小鼠中回收的麻风分枝杆菌只有0.2%具有活力，这表明用氨苯砜处理小鼠伴随着99.4%的活麻风分枝杆菌被杀死。
