Meerson F Z, Barbarash N A, Shorpin Iu P
Kardiologiia. 1977 Dec;17(12):71-9.
It was shown in experiments on 200 albino rats that prolonged adaptation to the periodical effect of hypoxia in an altitude chamber always resulted in partial atrophy of the adrenal glomerular zone and decrease in the synthesis of mineralocorticoids in the adrenals and in their concentration in blood. At the same time, the size of the supraoptic hypothalamic nuclei and their cytogically determined activity diminished. These structurally fixed adaptational changes in the hormonal control caused a stable decrease in the reseves of sodium and water in the organism of the adapted animals. This complex of shifts is contrary to the changes developing in all forms of experimental hypertension and in hypertensive disease in humans. The idea is discussed that inhibition of mineralocorticoid and ACTH secretion and the stable decrease in the sodium and water reserves in the organism during adaptation play the principal role in the mechanism of the preventive effect of adaption to altitude hypoxia in hypertension.
在对200只白化大鼠进行的实验中发现，在海拔舱内长期适应周期性缺氧效应总是导致肾上腺球状带部分萎缩，肾上腺中盐皮质激素的合成及其在血液中的浓度降低。与此同时，视上核的大小及其细胞活性降低。激素控制方面这些结构上固定的适应性变化导致适应动物体内钠和水储备的稳定减少。这种一系列变化与各种形式的实验性高血压以及人类高血压疾病中发生的变化相反。文中讨论了这样一种观点，即在适应过程中盐皮质激素和促肾上腺皮质激素分泌的抑制以及机体中钠和水储备的稳定减少在高原缺氧适应对高血压预防作用的机制中起主要作用。
