[墨西哥高尿酸血症和痛风的各种流行病学特征：发病率及心血管危险因素]
[Various epidemiological aspects of hyperuricemia and gout in Mexico: incidence and the cardiovascular risk factor].
作者信息
Robles Gil J, Armas C
出版信息
Arch Inst Cardiol Mex. 1978 Nov-Dec;48(6):1121-41.
We studied the prevalence and the risk factor among the patients of gout in Mexico. Research was conducted in the National Institute of Cardiology and in our private practice. Prevalence of hiperuricemia and gout in the Institute of Cardiology was of 1% (970 out of nearly 100,000 patients). We divided those cases of two subgroups: Reumatology patients (333) and Cardiovascular patients (529). In the first group primary gout was (96.3), and (50.32% in the second. Risk factor was quite different too: nephropathy 9.9%, lithiasis 9.3%, pyelonephritis 2.7%, cardioangiosclerosis 12.9%, aortosclerosis 6.6%, coronary insufficiency 6.3%, myocardial infarction 0.9%, arterial hypertension 24.6% obesity 56.1% and diabetes 9.9% in the Reumatology group; in the Cardiovascular one, nephropathy 14.3%, lithiasis 12.2%, pyelonephritis 7.1%, cardioangiosclerosis 62.7%, aortosclerosis 31.7%, coronary insufficiency 24.9%, myocardial infarction 29%, arterial hypertension 51%, obesity 54.8% and diabetes 20.4%. Among the private practice patients prevalence was of 10.1% (961). In an early age (39 years) in men and a later one for women (53 years). Other characteristics of epidemiology and risk factor are: primary gout 89%, atherosclerosis 5%, coronary disease 4.6%, lithiasis 4.7%, nephropathy 2%, pyelonephritis 1%, obesity 43%, and diabetes 4.6%. In an small group of patients of our private practice we made an exhaustive study of risk factor and the metabolic disorder of lipids. We found the following frequency: 9.3 of nephropathy, 31.2% of lithiasis, 18.7% of pyelonephritis, 68.9% of cardioangiosclerosis, 46.8% de coronary insufficiency, 9.3% of myocardial infarction, 68.7% of arterial hypertension, 68.7% of obesity and 18.7% of diabetes. In the lipid profile we found an increase in triglicerids and prebeta lipoprotein. We have amply discussed the relation between hiperuricemia and pathology considered as a risk factor from the genetic point of view as well as the metabolic and circumstancial aspect. From all that we concluded that risk is multifactorial.
我们研究了墨西哥痛风患者的患病率及风险因素。研究在国家心脏病学研究所及我们的私人诊所开展。心脏病学研究所高尿酸血症和痛风的患病率为1%（近10万名患者中有970例）。我们将这些病例分为两个亚组：风湿病患者（333例）和心血管病患者（529例）。第一组原发性痛风占96.3%，第二组占50.32%。风险因素也有很大差异：风湿病组中，肾病9.9%、结石9.3%、肾盂肾炎2.7%、心血管硬化12.9%、主动脉硬化6.6%、冠状动脉供血不足6.3%、心肌梗死0.9%、动脉高血压24.6%、肥胖56.1%、糖尿病9.9%；心血管病组中，肾病14.3%、结石12.2%、肾盂肾炎7.1%、心血管硬化62.7%、主动脉硬化31.7%、冠状动脉供血不足24.9%、心肌梗死29%、动脉高血压51%、肥胖54.8%、糖尿病20.4%。私人诊所患者的患病率为10.1%（961例）。男性发病年龄较早（39岁），女性较晚（53岁）。其他流行病学特征及风险因素如下：原发性痛风89%、动脉粥样硬化5%、冠心病4.6%、结石4.7%、肾病2%、肾盂肾炎1%、肥胖43%、糖尿病4.6%。在我们私人诊所的一小部分患者中，我们对风险因素及脂质代谢紊乱进行了详尽研究。我们发现以下频率：肾病9.3%、结石31.2%、肾盂肾炎18.7%、心血管硬化68.9%、冠状动脉供血不足46.8%、心肌梗死9.3%、动脉高血压68.7%、肥胖68.7%、糖尿病18.7%。在血脂谱方面，我们发现甘油三酯和前β脂蛋白升高。我们已从遗传角度以及代谢和环境方面充分讨论了高尿酸血症与被视为风险因素的病理之间的关系。由此我们得出结论，风险是多因素的。
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