Parc F, Tetaria C, Pichon G
Med Trop (Mars). 1981 Jan-Feb;41(1):97-102.
Authors report some accurate epidemiologic and physiopathologic data about dengue 4. Thanks to virus intrathoracic inoculation in Toxorhynchites amboinensis (Doleshall, 1857), 202 viral strains have been isolated from 633 sera samples. The incidence of the disease has decreased very early after immunization of the whole population and resulted in an eradication of dengue type 1 virus which was endemic in French Polynesia since 1976. Only one type of dengue virus seems to be tolerated in French Polynesian ecosystem in the same time. There is no crossing protection with dengue 1. Clinically, the picture has been the same in both new and previously infected by dengue 1 patients. Duration of viremia during the secondary dengue fever is not shorter than in the primary one. The hemagglutination inhibiting antibodies do not protect patients, but do not result in immune-complexes pathology.
作者报告了一些关于登革热4型准确的流行病学和生理病理学数据。通过在amboinensis巨蚊（Doleshall，1857年）体内进行胸腔内接种病毒，已从633份血清样本中分离出202株病毒株。在对全体人群进行免疫接种后，该病的发病率很早就开始下降，并导致自1976年以来在法属波利尼西亚流行的登革热1型病毒被根除。在法属波利尼西亚生态系统中，同一时间似乎只能耐受一种登革热病毒。与登革热1型没有交叉保护作用。临床上，新感染登革热的患者和先前感染过登革热1型的患者症状相同。二次登革热发热期间病毒血症的持续时间并不比初次感染时短。血凝抑制抗体不能保护患者，但也不会导致免疫复合物病理改变。
