Johannsen U, Mehlhorn G, Koch F, Neumeister K, Panndorf H
Arch Exp Veterinarmed. 1978;32(4):537-56.
Whole-body X-ray treatment was experimentally applied (380 median-line dosage) to eight Merino mutton sheep aged approximately one year. Five of the test animals were lost between 16 and 25 days after irradiation. A great diversity of pathomorphological changes was recorded from organs and tissues, and the most important pathological processes which occurred concomitantly with acute to subacute radiation syndrome of sheep were defective haematopoiesis, septico-toxic processes, haemorrhagic diathesis, and partial epilation. Severe damage to the organs involved in haematopoiesis was one of the primary pathological processes and reflected mainly in lymphopenia, agranulocytosis, and thrombocytopenia, in other words, with lymphopoieses, granulopoiesis, and thrombocytopoiesis particularly involved. Insufficiency of cellular (and humoral) defence would obviously cause germ flooding of the organism, starting from the intestine, and eventually lead to septic intoxication. Haemorrhagic diathesis was found to occur only short of death and is thought to result from thrombocytopenia due to damage to thrombopoiesis as well as from septico-toxic effects upon the blood coagulation and partitioning vascular system. Loss of wool (epilation) was recordable only from neck and shoulder regions, and even there it was on the decline.
对8只年龄约1岁的美利奴肉羊进行了全身X射线治疗实验（中线剂量为380）。5只受试动物在照射后16至25天内死亡。在器官和组织中记录到了多种多样的病理形态学变化，与绵羊急性至亚急性辐射综合征同时发生的最重要病理过程是造血功能缺陷、败血症-中毒过程、出血素质和局部脱毛。参与造血的器官受到严重损害是主要病理过程之一，主要表现为淋巴细胞减少、粒细胞缺乏和血小板减少，也就是说，淋巴细胞生成、粒细胞生成和血小板生成尤其受到影响。细胞（和体液）防御功能不足显然会导致病原体从肠道开始在体内大量繁殖，最终导致败血症中毒。出血素质仅在濒死时出现，被认为是由于血小板生成受损导致血小板减少以及败血症对凝血和血管系统的毒性作用所致。脱毛现象仅在颈部和肩部区域出现，而且即使在这些部位也在减少。
