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因长期摄入甘草导致全身钾耗竭和严重肌病。

Total body potassium depletion and severe myopathy due to chronic liquorice ingestion.

作者信息

Sundaram M B, Swaminathan R

出版信息

Postgrad Med J. 1981 Jan;57(663):48-9. doi: 10.1136/pgmj.57.663.48.

DOI:10.1136/pgmj.57.663.48
PMID:7279826
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2424759/
Abstract

A 33-year-old patient with hypokalaemia associated with severe myopathy following liquorice ingestion is described. Potassium depletion was confirmed by total body potassium measurements and myopathy was established by electromyography and enzyme studies. The potential hazard of chronic liquorice consumption even as a sweet is illustrated by this case.

摘要

本文描述了一名33岁的患者,在摄入甘草后出现低钾血症并伴有严重肌病。通过全身钾测量证实了钾缺乏,通过肌电图和酶学研究确诊了肌病。该病例说明了长期食用甘草(即使作为甜味剂)的潜在危害。

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Total body potassium depletion and severe myopathy due to chronic liquorice ingestion.因长期摄入甘草导致全身钾耗竭和严重肌病。
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Adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality.植物性食品补充剂和植物制剂的不良反应:一项对因果关系进行批判性评估的系统评价
Br J Clin Pharmacol. 2015 Apr;79(4):578-92. doi: 10.1111/bcp.12519.
3
Hypokalemic myopathy associated with liquorice ingestion.与食用甘草相关的低钾性肌病。
Ital J Neurol Sci. 1984 Dec;5(4):463-6. doi: 10.1007/BF02042634.

本文引用的文献

1
Effect of glycyrrhizinic acid on the electrolyte metabolism in Addison's disease.甘草酸对艾迪生病电解质代谢的影响。
J Clin Invest. 1952 Jan;31(1):87-91. doi: 10.1172/JCI102581.
2
Extract of licorice for the treatment of Addison's disease.用于治疗艾迪生病的甘草提取物。
N Engl J Med. 1951 Mar 29;244(13):471-5. doi: 10.1056/NEJM195103292441303.
3
Inhibition of the "mineralocorticoid" activity of licorice by spironolactone.螺内酯对甘草“盐皮质激素”活性的抑制作用。
J Clin Endocrinol Metab. 1962 Nov;22:1156-9. doi: 10.1210/jcem-22-11-1156.
4
Preparation of glycyrrhizinic acid, the electrolyte-active principle of licorice: its effects upon metabolism and upon pituitary-adrenal function in man.甘草的电解质活性成分甘草次酸的制备:其对人体新陈代谢及垂体 - 肾上腺功能的影响。
J Lab Clin Med. 1956 Jan;47(1):20-8.
5
Effects of liquorice and its derivatives on salt and water metabolism.甘草及其衍生物对盐和水代谢的影响。
Lancet. 1953 Apr 4;1(6762):663-8. doi: 10.1016/s0140-6736(53)91801-7.
6
Hypokalemic myopathy with myoglobinuria associated with licorice ingestion.与摄入甘草相关的低钾性肌病伴肌红蛋白尿。
N Engl J Med. 1966 Mar 17;274(11):602-6. doi: 10.1056/NEJM196603172741104.
7
Licorice-induced pseudoaldosteronism. Hypertension, hypokalemia, aldosteronopenia, and suppressed plasma renin activity.
JAMA. 1968 Aug 12;205(7):492-6. doi: 10.1001/jama.205.7.492.
8
Metabolic effects of liquorice.甘草的代谢作用。
Br Med J. 1977 Apr 2;1(6065):906. doi: 10.1136/bmj.1.6065.906-b.