Nielsen Mette Lundgren, Pareek Manan, Andersen Inger
Kardiologisk Afdeling Y, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 København NV, Denmark.
Ugeskr Laeger. 2012 Apr 9;174(15):1024-5.
Consumption of large amounts of liquorice can cause hypertension and hypokalaemia. Liquorice contains glycyrrhetinic acid, which inhibits the enzyme 11 beta-hydroxysteroid dehydrogenase type 2, and ultimately leads to an apparent mineralocorticoid excess syndrome. This case report describes a 50 year-old woman presenting with hypertension and hypokalaemia-induced limb paresis due to chronic liquorice ingestion. The patient was treated with potassium supplementation and spironolactone. Her blood pressure and electrolyte status normalised within a month after cessation of liquorice intake.
大量食用甘草会导致高血压和低钾血症。甘草含有甘草次酸，它会抑制2型11β-羟基类固醇脱氢酶，最终导致明显的盐皮质激素过多综合征。本病例报告描述了一名50岁女性，因长期摄入甘草而出现高血压和低钾血症所致的肢体麻痹。患者接受了补钾和螺内酯治疗。停止摄入甘草后一个月内，她的血压和电解质状况恢复正常。
