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[甘草引起的高血压和低钾血症]

[Liquorice-induced hypertension and hypokalaemia].

作者信息

Nielsen Mette Lundgren, Pareek Manan, Andersen Inger

机构信息

Kardiologisk Afdeling Y, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 København NV, Denmark.

出版信息

Ugeskr Laeger. 2012 Apr 9;174(15):1024-5.

Abstract

Consumption of large amounts of liquorice can cause hypertension and hypokalaemia. Liquorice contains glycyrrhetinic acid, which inhibits the enzyme 11 beta-hydroxysteroid dehydrogenase type 2, and ultimately leads to an apparent mineralocorticoid excess syndrome. This case report describes a 50 year-old woman presenting with hypertension and hypokalaemia-induced limb paresis due to chronic liquorice ingestion. The patient was treated with potassium supplementation and spironolactone. Her blood pressure and electrolyte status normalised within a month after cessation of liquorice intake.

摘要

大量食用甘草会导致高血压和低钾血症。甘草含有甘草次酸,它会抑制2型11β-羟基类固醇脱氢酶,最终导致明显的盐皮质激素过多综合征。本病例报告描述了一名50岁女性,因长期摄入甘草而出现高血压和低钾血症所致的肢体麻痹。患者接受了补钾和螺内酯治疗。停止摄入甘草后一个月内,她的血压和电解质状况恢复正常。

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