Quatrini U, Licciardi A
Boll Soc Ital Biol Sper. 1983 Apr 30;59(4):553-9.
In the previous researches we found that the albino rats of Wistar stock, raised from the time of birth under hypoxia at simulated altitude, showed a displacement of the acid-base balance of blood towards the acid side and an increase in the 2,3-DPG, in Hb concentration and in the number of erythrocytes for mm3 of blood. In the same animals the body growth was slower in comparison to the control normoxic group. In order to separate the eventual effects of hypobaria from those of hypoxia "per se" we have repeated our research in normobaric hypoxic environment for 51 days as minimum period and 86 as maximum period of observation. The samples of blood were collected with heart drawing. The acid-base balance was determined by a hemogas-analyzer IL 213, the lactacidemia with the Boehringer enzyme tests. The animals showed again a displacement of the acid-base balance of blood towards the acid side. Nevertheless this phenomenon was less accentuated than in hypobaric conditions. The Weight curve of hypoxic animals superimposed to normoxic controls until 35 degree days. Thereafter the two curves turned apart within 20%.
在先前的研究中，我们发现，从出生起就在模拟海拔的低氧环境中饲养的Wistar品系白化大鼠，其血液酸碱平衡向酸性方向偏移，同时每立方毫米血液中的2,3-二磷酸甘油酸（2,3-DPG）、血红蛋白（Hb）浓度和红细胞数量均增加。与对照常氧组相比，这些动物的身体生长较慢。为了区分低气压与低氧本身的最终影响，我们在常压低氧环境中重复了研究，观察期最短为51天，最长为86天。通过心脏采血采集血样。使用IL 213型血液气体分析仪测定酸碱平衡，用勃林格酶试验测定乳酸血症。这些动物再次出现血液酸碱平衡向酸性方向偏移的情况。然而，与低气压条件下相比，这种现象不太明显。低氧动物的体重曲线在35度日之前与常氧对照重叠。此后，两条曲线在20%的范围内分开。
