Quatrini U, Benigno A, Orlando F
Poumon Coeur. 1980;36(6):361-5.
Albino rats of the Wistar family were reared from the time of birth in a simulated altitude of about 6000 meters (barometric pressure 370 mm Hg) for a period of about 50 days. A number of these were killed after losing consciousness upon exposure to acute hypoxia. The others were killed without being first subjected to the acute hypoxia. Control groups of the same stock were reared for a corresponding period of time in a normal atmosphere at sea level and killed like the previous group. The animals reared in a simulated altitude displayed an increase in the 2,3-DPG content in the red blood cells, Hb concentration and the number of erythrocytes for one ml of blood. They are to be considered phenomena of adaptation, only slightly influenced by the acute hypoxia. The animals reared in a simulated altitude also displayed a displacement of the acid-base balance of the blood towards the acid side. This was even more accentuated in the group subjected to the acute hypoxia. It was observed, via the weight curve, that the animals reared in a simulated altitude presented a slower body growth in comparison to the control group. We were not able to demonstrate significant variations in the tolerance to acute hypoxia in the various groups studied.
将Wistar品系的白化大鼠从出生起就在约6000米的模拟海拔高度（气压370毫米汞柱）饲养约50天。其中一些大鼠在暴露于急性缺氧后失去意识时被处死。其他大鼠则未先经历急性缺氧就被处死。相同品系的对照组在海平面正常大气中饲养相应时间，并与前一组一样被处死。在模拟海拔高度饲养的动物，其红细胞中的2,3 - 二磷酸甘油酸（2,3 - DPG）含量、血红蛋白（Hb）浓度以及每毫升血液中的红细胞数量均有所增加。这些应被视为适应现象，仅受到急性缺氧的轻微影响。在模拟海拔高度饲养的动物，其血液酸碱平衡也向酸性方向偏移。在经历急性缺氧的组中这种情况更为明显。通过体重曲线观察到，与对照组相比，在模拟海拔高度饲养的动物身体生长较慢。在我们所研究的各个组中，未能证明对急性缺氧的耐受性存在显著差异。
