Davenport P W, Frazier D T, Zechman F W
Respir Physiol. 1981 Mar;43(3):299-314. doi: 10.1016/0034-5687(81)90111-0.
Anesthetized, spontaneously breathing cats were used to examine the hypothesized role of slowly adapting pulmonary stretch receptors (PSR) in the control of breath duration. Initially, graded inspiratory and expiratory resistive loads were added to elucidate the inspiratory and expiratory volume-time relationship with both vagi intact. Unilateral vagotomy increased the slope of the VI--TI relationship indicating a reduction of the volume related modulation of TI. PSR frequency (fPSR) at end-inspiration also progressively decreased resulting in a fPSR--TI relationship qualitatively similar to the VI--TI curve. Expiratory resistive loading also produced an increased slope for the VE--TE relationship when the right vagus nerve was severed. The prolongation of TE was associated with a progressive increase in the number of PSR discharges during the loaded expiration. These results support the hypothesized role of PSR in the vagally mediated prolongation of TI and TE during resistive loading. In a subsequent series of experiments, the changes in fPSR were correlated with the tidal volume and transpulmonary pressure (PTP) changes. The fPSR was linearly related to PTP during both eupnic and loaded breathing. When fPSR was plotted against volume, a clockwise hysteresis was observed. These results suggest that in the spontaneously breathing cat, intrathoracic PSR frequency varies as a function of the transmural pressure across the airways.
使用麻醉状态下自主呼吸的猫来研究慢适应性肺牵张感受器（PSR）在呼吸时长控制中假定的作用。最初，施加分级吸气和呼气阻力负荷，以阐明双侧迷走神经完整时吸气和呼气的容积 - 时间关系。单侧迷走神经切断术增加了VI - TI关系的斜率，表明TI的容积相关调节减少。吸气末的PSR频率（fPSR）也逐渐降低，导致fPSR - TI关系在质量上与VI - TI曲线相似。当右侧迷走神经切断时，呼气阻力负荷也使VE - TE关系的斜率增加。TE的延长与负荷呼气期间PSR放电次数的逐渐增加有关。这些结果支持了PSR在阻力负荷期间迷走神经介导的TI和TE延长中假定的作用。在随后的一系列实验中，fPSR的变化与潮气量和跨肺压（PTP）的变化相关。在平静呼吸和负荷呼吸期间，fPSR与PTP呈线性关系。当以fPSR对容积作图时，观察到顺时针滞后现象。这些结果表明，在自主呼吸的猫中，胸内PSR频率随气道跨壁压的变化而变化。
