Joller P W, Barandun S, Hitzig W H
Schweiz Med Wochenschr. 1980 Oct 4;110(40):1451-3.
The effect of an unmodified immunoglobulin for intravenous substitution in patients with antibody deficiency syndrome (ADS) has been studied. Over 100 doses of Sandoglobulin were administered to ADS patients without any sign of anaphylactoid reaction. There is no upper limit on the quantity infused. Peak values and basal values can be calculated and therapy can be adjusted accordingly. The halflife of the preparation equals that of native IgG in a healthy person. Comparing days with temperature above 38 degrees C (100.4 degrees F), days under antibiotics, and absence from work during equal periods with and without Sandoglobulin, the beneficial effect of this preparation is obvious. Sandoglobulin can be recommended for longterm therapy in ADS.
已对未修饰的静脉注射免疫球蛋白替代疗法对抗体缺乏综合征（ADS）患者的疗效进行了研究。已向ADS患者施用了100多剂Sandoglobulin，未出现任何类过敏反应迹象。输注量没有上限。可以计算峰值和基础值，并据此调整治疗方案。该制剂的半衰期与健康人天然IgG的半衰期相同。比较使用和不使用Sandoglobulin的相同时间段内体温高于38摄氏度（100.4华氏度）的天数、使用抗生素的天数以及缺勤天数，该制剂的有益效果显而易见。Sandoglobulin可推荐用于ADS的长期治疗。
