O'Brien I M, Harries M G, Burge P S, Pepys J
Clin Allergy. 1979 Jan;9(1):1-6. doi: 10.1111/j.1365-2222.1979.tb01516.x.
A group of twenty four workers handling di-isocyanates and with respiratory disease were investigated by occupational-type bronchial provocation tests for sensitivity to toluene di-isocyanate (TDI), to which all were exposed, and to diphenylmethane di-isocyanate (MDI) and hexamethylene di-isocyanate (HDI). Sixteen gave asthmatic reactions to TDI and eight of these also reacted to MDI. Four of the eight TDI and MDI reactors had histories of exposure only to TDI, and of them two reacted also to HDI. Of nine subjects tested with HDI, three gave asthmatic reactions, and all three also reacted to TDI and MDI. Thus reactions to MDI and HDI were elicited only in the TDI reactors. The possibility of specific sensitivity to these and other di-isocyanates requires tests in subjects exposed to them and not to TDI.
对一组24名接触二异氰酸酯且患有呼吸系统疾病的工人进行了职业性支气管激发试验，以检测他们对甲苯二异氰酸酯（TDI）、二苯基甲烷二异氰酸酯（MDI）和六亚甲基二异氰酸酯（HDI）的敏感性。所有工人均接触TDI，其中16人对TDI出现哮喘反应，这16人中的8人对MDI也有反应。在这8名对TDI和MDI有反应的工人中，有4人仅有接触TDI的病史，其中2人对HDI也有反应。在9名接受HDI检测的受试者中，3人出现哮喘反应，且这3人对TDI和MDI也有反应。因此，仅在对TDI有反应的受试者中引发了对MDI和HDI的反应。对于这些以及其他二异氰酸酯的特异性敏感性，需要在接触这些物质而非TDI的受试者中进行检测。
