巯基化合物可能介导胃细胞保护作用。
Sulfhydryl compounds may mediate gastric cytoprotection.
作者信息
Szabo S, Trier J S, Frankel P W
出版信息
Science. 1981 Oct 9;214(4517):200-2. doi: 10.1126/science.7280691.
Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol-induced gastric erosions, whereas sulfhydryl blocking agents counteract the mucosal cytoprotective effect of prostaglandin F2 beta. These observations suggest that endogenous nonprotein sulfhydryls may mediate prostaglandin-induced gastric cytoprotection and that sulfhydryl drugs may have potential for preventing or treating hemorrhagic gastric erosions.
乙醇可诱发大鼠胃黏膜出血性糜烂，并导致大鼠胃黏膜中非蛋白巯基化合物浓度呈剂量依赖性降低。含巯基的药物可保护大鼠免受乙醇诱发的胃黏膜糜烂，而巯基阻断剂则可抵消前列腺素F2β的黏膜细胞保护作用。这些观察结果表明，内源性非蛋白巯基可能介导前列腺素诱导的胃细胞保护作用，且巯基药物可能具有预防或治疗出血性胃黏膜糜烂的潜力。
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