Pirozzolo F J, Hansch E C
Science. 1981 Oct 16;214(4518):349-51. doi: 10.1126/science.7280699.
The effects of diffuse cerebral dysfunction on oculomotor reaction time were assessed in patients with dementia of presumed Alzheimer's etiology and in normal age-matched control subjects. Patients were classified into mild, moderate, and severe groups on the basis of independent neurological, neuropsychological, and neuroradiological ratings for disease severity. Saccadic latencies to targets appearing in parafoveal and near peripheral vision showed significant increases from the normal controls to dementia groups, with each severity subdivision clearly differentiated from the others in terms of mean oculomotor reaction time. These data offer strong evidence for a direct relationship between degree of cortical structural integrity and simple oculomotor reaction time and suggest a higher cortical regulatory role in sensory-motor integration.
在病因推测为阿尔茨海默病的痴呆患者以及年龄匹配的正常对照受试者中，评估了弥漫性脑功能障碍对动眼反应时间的影响。根据疾病严重程度的独立神经学、神经心理学和神经放射学评级，将患者分为轻度、中度和重度组。从正常对照组到痴呆组，向中央凹旁和近周边视野中出现的目标的扫视潜伏期显著增加，每个严重程度亚组在平均动眼反应时间方面都与其他亚组有明显差异。这些数据为皮质结构完整性程度与简单动眼反应时间之间的直接关系提供了有力证据，并表明在感觉运动整合中皮质具有更高的调节作用。
