神经退行性疾病中的眼球运动异常。
Ocular motor abnormalities in neurodegenerative disorders.
作者信息
Antoniades C A, Kennard C
机构信息
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford UK.
出版信息
Eye (Lond). 2015 Feb;29(2):200-7. doi: 10.1038/eye.2014.276. Epub 2014 Nov 21.
Abstract
Eye movements are a source of valuable information to both clinicians and scientists as abnormalities of them frequently act as clues to the localization of a disease process. Classically, they are divided into two main types: those that hold the gaze, keeping images steady on the retina (vestibulo-ocular and optokinetic reflexes) and those that shift gaze and redirect the line of sight to a new object of interest (saccades, vergence, and smooth pursuit). Here we will review some of the major ocular motor abnormalities present in neurodegenerative disorders.
摘要
眼球运动对临床医生和科学家来说都是有价值信息的来源，因为眼球运动异常常常是疾病进程定位的线索。传统上，眼球运动主要分为两大类：一类是保持注视，使图像稳定在视网膜上（前庭眼反射和视动反射）；另一类是转移注视并将视线重新指向新的感兴趣物体（扫视、聚散和平稳跟踪）。在此，我们将回顾神经退行性疾病中出现的一些主要眼球运动异常情况。
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本文引用的文献
1
Distinctive features of microsaccades in Alzheimer's disease and in mild cognitive impairment.
Age (Dordr). 2014 Apr;36(2):535-43. doi: 10.1007/s11357-013-9582-3. Epub 2013 Sep 15.
2
Antisaccade task reflects cortical involvement in mild cognitive impairment.
Neurology. 2013 Oct 1;81(14):1235-43. doi: 10.1212/WNL.0b013e3182a6cbfe. Epub 2013 Aug 28.
3
Saccadic abnormalities in frontotemporal dementia.
Neurology. 2012 Jun 5;78(23):1816-23. doi: 10.1212/WNL.0b013e318258f75c. Epub 2012 May 9.
4
Saccade abnormalities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer disease.
Arch Neurol. 2012 Apr;69(4):509-17. doi: 10.1001/archneurol.2011.1021.
5
Deep brain stimulation: eye movements reveal anomalous effects of electrode placement and stimulation.
PLoS One. 2012;7(3):e32830. doi: 10.1371/journal.pone.0032830. Epub 2012 Mar 12.
6
Triggering mechanisms in microsaccade and saccade generation: a novel proposal.
Ann N Y Acad Sci. 2011 Sep;1233:107-16. doi: 10.1111/j.1749-6632.2011.06177.x.
7
Huntington's disease: changes in saccades and hand-tapping over 3 years.
J Neurol. 2010 Nov;257(11):1890-8. doi: 10.1007/s00415-010-5632-2. Epub 2010 Jun 29.
8
Diagnostic potential of saccadometry in progressive supranuclear palsy.
Biomark Med. 2007 Dec;1(4):487-90. doi: 10.2217/17520363.1.4.487.
9
Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease.
Neurology. 2010 Mar 2;74(9):743-8. doi: 10.1212/WNL.0b013e3181d31e0b.
10
Antisaccades: a probe into the dorsolateral prefrontal cortex in Alzheimer's disease. A critical review.
J Alzheimers Dis. 2010;19(3):781-93. doi: 10.3233/JAD-2010-1275.
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