Kort H I, Cassel G A
S Afr Med J. 1981 Oct 10;60(15):578-9.
A retrospective analysis of 40 patients with cardiac disease who received sodium warfarin (Coumadin) therapy during pregnancy has been performed. The fetal mortality was 12,5%, but no case of congenital epiphyseal stippling was detected. The incidence of maternal postpartum haemorrhage was high. Warfarin should whenever possible be withheld during the 1st trimester of pregnancy and replaced by heparin.
对40例在孕期接受华法林钠（香豆素）治疗的心脏病患者进行了回顾性分析。胎儿死亡率为12.5%，但未发现先天性骨骺点状钙化的病例。产妇产后出血的发生率较高。孕期头三个月应尽可能停用华法林，改用肝素。
