Iida H, Nakamoto Y, Kobayashi K, Dohi K, Hattori N, Takeuchi J
Virchows Arch A Pathol Anat Histol. 1981;392(1):55-62. doi: 10.1007/BF00430548.
A possible role of HBsAg in hepatic glomerulonephritis was evaluated in kidney specimens from 104 patients with various diseases. Huang's method using formalin-fixed and paraffin-embedded sections was applied to the kidney from 65 cases. Only 4 (3.8%) with liver cirrhosis had glomerular HBsAg deposition; 3 on frozen and one on paraffin sections. In one case of crescentic glomerulonephritis, HBsAg appeared to have had a pathogenetic role with glomerular immunofluorescence dominant for IgM, less intense IgG and negative IgA. The glomerular HBsAg in the remaining 3 patients with hepatic IgA glomerulonephritis was likely to be concomitant or superimposed. One of them had a nephrotic syndrome for which corticosteroid treatment was given, resulting in a near-complete remission and disappearance of HBsAg in the glomeruli, but the glomerular immunohistology was unaffected by the treatment. The present findings suggest that HBsAg has only a minor role.
在104例患有各种疾病患者的肾脏标本中评估了乙肝表面抗原（HBsAg）在肝性肾小球肾炎中的可能作用。对65例患者的肾脏采用了黄氏方法，即使用福尔马林固定和石蜡包埋切片。仅4例（3.8%）肝硬化患者肾小球有HBsAg沉积；3例在冰冻切片上，1例在石蜡切片上。在1例新月体性肾小球肾炎中，HBsAg似乎具有致病作用，肾小球免疫荧光以IgM为主，IgG强度较弱，IgA阴性。其余3例肝性IgA肾小球肾炎患者的肾小球HBsAg可能是伴随或叠加的。其中1例患有肾病综合征，接受了皮质类固醇治疗，导致病情近乎完全缓解且肾小球中HBsAg消失，但治疗未影响肾小球免疫组织学。目前的研究结果表明HBsAg仅起次要作用。
