婴幼儿脑脊液中高肌肽的研究。第一部分。正常婴幼儿脑脊液中的高肌肽水平。

Studies on homocarnosine in cerebrospinal fluid in infancy and childhood. Part I. Homocarnosine level in cerebrospinal fluid of normal infants and children.

作者信息

Takahashi H

出版信息

Brain Dev. 1981;3(3):255-61. doi: 10.1016/s0387-7604(81)80047-2.

Abstract

Homocarnosine levels in the cerebrospinal fluid of 49 normal infants and children were determined by a high speed amino acid autoanalyzer (Hitachi Co.). The mean homocarnosine level in cerebrospinal fluid (CSF) of infants and children was 0.75 +/- 0.24 mumol/dl. In infants under 2 years of age, significant correlation between homocarnosine levels in CSF and the gestational age was found (r = 0.79, p less than 0.001). In children from 2 to 8 years of age, homocarnosine levels in CSF were almost constant being independent of the age (mean +/- SD: 0.89 +/- 0.20 mumol/dl). In school children over 9 years of age, significant correlation between homocarnosine levels in CSF and the age was found ( r = -0.68, p less than 0.01).

摘要

采用高速氨基酸自动分析仪（日立公司）测定了49例正常婴幼儿脑脊液中的高肌肽水平。婴幼儿脑脊液中高肌肽的平均水平为0.75±0.24μmol/dl。在2岁以下的婴幼儿中，发现脑脊液中高肌肽水平与胎龄之间存在显著相关性（r = 0.79，p < 0.001）。在2至8岁的儿童中，脑脊液中高肌肽水平几乎恒定，与年龄无关（平均值±标准差：0.89±0.20μmol/dl）。在9岁以上的学龄儿童中，发现脑脊液中高肌肽水平与年龄之间存在显著相关性（r = -0.68，p < 0.01）。