格鲁米特在人体内诱导肝酶的特征。
The features of hepatic enzyme induction with glutethimide in man.
作者信息
Jackson L, Homeida M, Roberts C J
出版信息
Br J Clin Pharmacol. 1978 Dec;6(6):525-8. doi: 10.1111/j.1365-2125.1978.tb00877.x.
Abstract
1 Sequential measurements of D-glucaric acid excretion were made in six healthy volunteers before, during and after 3 weeks' daily medication with glutethimide 500 mg. 2 There was a rapid rise in D-glucaric acid excretion within 2 days of starting medication and a rapid decline when it was stopped. 3 Antipyrine clearance and indocyanine green clearance were measured before and at the end of the 3 weeks' medication. 4 There was a 55% increase in antipyrine clearance but no change in indocyanine green clearance. 5 There was no correlation between antipyrine clearance and D-glucaric acid excretion. 6 Glutethimide causes rapid enzyme induction in man without concomitant rise in hepatic blood flow.
摘要
- 对6名健康志愿者在每日服用500毫克格鲁米特3周之前、期间和之后进行了D - 葡糖二酸排泄的连续测量。2. 开始用药后2天内D - 葡糖二酸排泄迅速增加，停药时迅速下降。3. 在用药3周前和结束时测量了安替比林清除率和吲哚菁绿清除率。4. 安替比林清除率增加了55%，但吲哚菁绿清除率没有变化。5. 安替比林清除率与D - 葡糖二酸排泄之间没有相关性。6. 格鲁米特在人体内可迅速诱导酶，而肝血流量无相应增加。
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