人体肝脏血流估计中的生理和药理变异性。
Physiological and pharmacological variability in estimated hepatic blood flow in man.
作者信息
Daneshmend T K, Jackson L, Roberts C J
出版信息
Br J Clin Pharmacol. 1981 May;11(5):491-6. doi: 10.1111/j.1365-2125.1981.tb01155.x.
Abstract
1 Changes in hepatic blood flow have been estimated by measurement of single-dose indocyanine green kinetics in groups of healthy individuals. 2 The effects of change in posture, exercise and ingestion of milk on estimated hepatic blood flow have been assessed. 3 The erect posture and exercise significantly decreased ICG clearance. However, no consistent change was noted after ingestion of milk. 4 The effects of the adrenoceptor blocking drugs phenoxybenzamine, propranolol and labetalol on hepatic blood flow were also assessed. 5 Propranolol and labetalol caused a significant fall in ICG clearance in the supine position. Phenoxybenzamine did not show a consistent change. 6 Posture, exercise and adrenoceptor blockade appear to be important variables affecting hepatic blood flow. They should be considered when kinetics of high-clearance drugs are measured, and may provide a useful model for the assessment of the effects of alterations in hepatic blood flow on the clearance of drugs.
摘要
1 通过测量健康个体组中单剂量吲哚菁绿动力学来估计肝血流量的变化。2 评估了姿势改变、运动和摄入牛奶对估计肝血流量的影响。3 直立姿势和运动显著降低了吲哚菁绿清除率。然而，摄入牛奶后未观察到一致的变化。4 还评估了肾上腺素能受体阻断药物苯氧苄胺、普萘洛尔和拉贝洛尔对肝血流量的影响。5 普萘洛尔和拉贝洛尔在仰卧位时导致吲哚菁绿清除率显著下降。苯氧苄胺未显示出一致的变化。6 姿势、运动和肾上腺素能受体阻断似乎是影响肝血流量的重要变量。在测量高清除率药物的动力学时应予以考虑，并且可能为评估肝血流量改变对药物清除率的影响提供一个有用的模型。
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