[14C] -氨基比林呼气试验。不同分析形式的比较。
The [14C]-aminopyrine breath test. A comparison of different forms of analysis.
作者信息
Henry D A, Sharpe G, Chaplain S, Cartwright S, Kitchingman G, Bell G D, Langman M J
出版信息
Br J Clin Pharmacol. 1979 Dec;8(6):539-45. doi: 10.1111/j.1365-2125.1979.tb01041.x.
Abstract
1 Following ingestion of [14C]-aminopyrine, breath 14CO2 data were analysed from normal individuals, patients with hepatic disease, epileptics receiving anticonvulsant therapy and volunteers before and after treatment with glutethimide. 2 The 'standard' 2 h [14C]-aminopyrine breath test discriminated successfully between the main groups but failed to detect the change in microsomal enzyme function produced by glutethimide. 3 A 'modified' form of the 2 h breath test calculated from the area under the breath specific activity curve detected the increase in demethylation following glutethimide. 4 The breath elimination constant (Kb) derived from the breath 14CO2 disappearance curve was as sensitive as the 'modified' 2 h breath test and was simpler to compute. 5 Glutethimide 500 mg/day for 14 days resulted in a 42% increase in the metabolic clearance of antipyrine and a 26% increase in demethylation of [14C]-aminopyrine.
摘要
- 摄入[14C]-氨基比林后，分析了正常个体、肝病患者、接受抗惊厥治疗的癫痫患者以及服用格鲁米特前后志愿者的呼出14CO2数据。2. “标准”的2小时[14C]-氨基比林呼气试验成功地区分了主要组别，但未能检测到格鲁米特引起的微粒体酶功能变化。3. 根据呼气比活性曲线下面积计算的2小时呼气试验的“改良”形式检测到了格鲁米特后去甲基化的增加。4. 从呼出14CO2消失曲线得出的呼气消除常数（Kb）与“改良”的2小时呼气试验一样敏感，且计算更简单。5. 每天服用500毫克格鲁米特，持续14天，导致安替比林的代谢清除率增加42%，[14C]-氨基比林的去甲基化增加26%。
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本文引用的文献
1
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J Nucl Med. 1970 Dec;11(12):711-5.
2
Urinary D-glucaric acid assay by an improved enzymatic procedure.采用改进的酶法测定尿中D-葡糖二酸
Clin Chim Acta. 1974 Feb 28;51(1):47-51. doi: 10.1016/0009-8981(74)90060-6.
3
Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis.口服14C-氨基比林后通过呼吸分析评估人体中氨基比林的代谢。苯巴比妥、双硫仑和门脉性肝硬化的影响。
N Engl J Med. 1974 Dec 26;291(26):1384-8. doi: 10.1056/NEJM197412262912605.
4
Effect of subacute administration of methaqualone, phenobarbital and glutethimide on plasma levels of bishydroxycoumarin.
Arch Int Pharmacodyn Ther. 1972 Jan;195(1):185-91.
5
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6
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Clin Pharmacol Ther. 1976 Oct;20(4):484-92. doi: 10.1002/cpt1976204484.
7
8
Aminopyrine metabolism in the presence of hyperbilirubinemia due to cholestasis or hepatocellular disease. Combined use of laboratory tests to study disease-induced alterations in drug disposition.
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