大鼠离体灌注肺及肺匀浆中5-羟色胺、多巴胺和β-苯乙胺摄取与脱氨基作用的个体发生
Ontogenesis of uptake and deamination of 5-hydroxytryptamine, dopamine and beta-phenylethylamine in isolated perfused lung and lung homogenates from rats.
作者信息
Ben-Harari R R, Youdim M B
出版信息
Br J Pharmacol. 1981 Apr;72(4):731-7. doi: 10.1111/j.1476-5381.1981.tb09155.x.
Abstract
- Uptake of 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PEA) was studied in perfused lung from male rats between 10 and 70 days old. 2. Monoamine oxidase (MAO) activity towards 5-HT, PEA and dopamine was studied in homogenate preparations of lung from rats aged between 5 and 80 days. 3. Uptake of 5-HT (10 microM) decreased throughout the age range studied but uptake of PEA (50 microM) increased for the first 30 days and beyond this age it decreased. Metabolites formed for both amines reflected the changes in uptake. 4. MAO activity deaminating 5-HT is well developed by day 10 and reaches its maximum by day 40. For dopamine and PEA, MAO activity remained low until day 20, and the developed rapidly, reaching a maximum by day 40 for dopamine; activity towards PEA did not reach a maximum by day 80. 5. These results show that uptake and MAO activity changes with age and thus the lung responds like other tissues. 6. These results also demonstrate the independent development of uptake and MAO activity towards 5-HT, PEA and dopamine.
摘要
- 研究了10至70日龄雄性大鼠灌注肺中5-羟色胺（5-HT）和β-苯乙胺（PEA）的摄取情况。2. 研究了5至80日龄大鼠肺匀浆制剂中对5-HT、PEA和多巴胺的单胺氧化酶（MAO）活性。3. 在整个研究的年龄范围内，5-HT（10微摩尔）的摄取量下降，但PEA（50微摩尔）的摄取量在最初30天增加，超过这个年龄则下降。两种胺形成的代谢产物反映了摄取的变化。4. 脱氨5-HT的MAO活性在第10天发育良好，并在第40天达到最大值。对于多巴胺和PEA，MAO活性直到第20天仍较低，然后迅速发育，多巴胺在第40天达到最大值；对PEA的活性在第80天未达到最大值。5. 这些结果表明，摄取和MAO活性随年龄变化，因此肺与其他组织的反应相似。6. 这些结果还证明了对5-HT、PEA和多巴胺的摄取和MAO活性的独立发育。
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