大鼠脑区中[3H]-多巴胺和[3H]-5-羟色胺摄取系统的伴随发育。
Concomitant development of [3H]-dopamine and [3H]-5-hydroxytryptamine uptake systems in rat brain regions.
作者信息
Kirksey D F, Slotkin T A
出版信息
Br J Pharmacol. 1979 Nov;67(3):387-91. doi: 10.1111/j.1476-5381.1979.tb08692.x.
Abstract
1 Synaptosomal uptake mechanisms of 5-hydroxytryptamine and dopamine were examined in cerebral cortex, corpus striatum and midbrain plus brainstem of developing rats. 2 In all regions, there was generally a parallel biphasic development of both uptake systems; the most rapid increases occurred in the first two weeks postpartum, followed by a slower rate of increase. 3 Kinetic studies with dopamine indicated that the maturation involved increases in maximal uptake without a change in the substrate Km, suggesting that there is a change in the number or terminals but not in the uptake system per se.
摘要
- 在发育中大鼠的大脑皮层、纹状体以及中脑加脑干中，研究了5-羟色胺和多巴胺的突触体摄取机制。2. 在所有区域，这两种摄取系统总体上呈现平行的双相发育；产后前两周增长最为迅速，随后增速减缓。3. 对多巴胺的动力学研究表明，成熟过程涉及最大摄取量的增加，而底物米氏常数（Km）不变，这表明是末梢数量发生了变化，而非摄取系统本身发生了变化。
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